Succinate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Succinate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPF1, CLIC6, and ESD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinate transmembrane transport activity versus RPF1 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPF1 →	+0.386	+0.071	<.001	<.001	3	5
BRCA	CLIC6 →	-1.082	-0.065	<.001	<.001	3	5
COAD	ESD →	-0.390	-0.069	<.001	<.001	3	5
BRCA	GINS3 →	+0.719	+0.083	<.001	<.001	3	5
BRCA	HK3 →	+0.776	+0.070	<.001	<.001	3	5
LUAD	NCF4 →	+0.364	+0.075	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071422 vs RPF1 — BRCA

Explore this scatter interactively →