Succinate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Succinate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A1, AKR7A2P1, and ACSS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinate transmembrane transport activity versus SLC16A1 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC16A1 →	+1.009	+0.306	<.001	<.001	3	8
UCEC	AKR7A2P1 →	+0.708	+0.238	<.001	<.001	3	6
OV	ACSS3 →	-0.548	-0.201	.002	<.001	3	4
HNSC	KLHL29 →	-0.647	-0.266	<.001	<.001	3	4
HNSC	L3MBTL4-AS1 →	-0.904	-0.238	<.001	<.001	3	4
LUAD	CERT1 →	-0.296	-0.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071422 vs SLC16A1 — UCEC

Explore this scatter interactively →