Succinate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Succinate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DISP1, ACBD5, and LYST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DISP1 grouped by Succinate transmembrane transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DISP1 →	+0.778	+1.421	.001	<.001	2	5
LUNG_NSCLC_LUAD	ACBD5 →	+0.543	+0.840	.003	<.001	3	4
LARGE_INTESTINE	LYST →	+0.748	+1.180	<.001	.002	3	3
BLOOD_Lymphoma	NLRC3 →	-4.085	-1.314	<.001	<.001	3	3
BLOOD_Lymphoma	ZNF608 →	-4.189	-1.314	<.001	<.001	3	3
SKIN	CCDC113 →	+0.592	+0.767	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DISP1 by Succinate transmembrane transport activity — LARGE_INTESTINE

Explore this box plot interactively →