Cellular response to histamine

Across TCGA patient cohorts, RNA activity of the Cellular response to histamine pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTATIP2, ITSN1, and CDCP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to histamine activity versus HTATIP2 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HTATIP2 →	+0.425	+0.068	<.001	<.001	3	5
BRCA	ITSN1 →	-0.262	-0.071	<.001	<.001	3	5
CCRCC	CDCP1 →	+0.906	+0.120	<.001	.002	3	5
HNSC	ZC2HC1A →	-0.364	-0.138	<.001	<.001	3	5
HNSC	FAM83H →	+0.505	+0.126	.005	.001	3	5
LSCC	FAM83H_S523 →	+0.728	+0.094	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071420 vs HTATIP2 — BRCA

Explore this scatter interactively →