Cellular response to histamine

Across TCGA patient cohorts, RNA activity of the Cellular response to histamine pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOB4P2, ARL14, and NOS1AP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to histamine activity versus MOB4P2 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MOB4P2 →	+0.464	+0.525	<.001	.001	3	4
PDAC	ARL14 →	+1.014	+0.411	<.001	.003	3	3
BRCA	NOS1AP →	-0.785	-0.643	<.001	<.001	3	3
OV	SLC19A2 →	-0.602	-0.343	.001	.006	3	3
LUAD	INTS11 →	-0.213	-0.429	.005	<.001	3	3
GBM	LMO2 →	+0.614	+0.250	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071420 vs MOB4P2 — LSCC

Explore this scatter interactively →