Cellular response to histamine

Across TCGA cell cohorts, RNA activity of the Cellular response to histamine pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf144, GOT1, and WSB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C20orf144 grouped by Cellular response to histamine-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C20orf144 →	-0.205	-1.091	.004	.003	3	4
OVARY	GOT1 →	+0.813	+1.164	<.001	<.001	3	4
BLOOD_Leukemia	WSB2 →	-1.329	-1.170	.007	.002	3	4
BLOOD_Leukemia	RHBDD2 →	-0.973	-1.097	.002	.007	3	4
BONE	LRRC41 →	-0.802	-1.630	.006	<.001	3	4
CNS	STEAP3 →	-0.984	-0.685	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C20orf144 by Cellular response to histamine activity — CNS

Explore this box plot interactively →