Cellular response to progesterone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to progesterone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are N4BP2, SRSF9, and RNF166, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, N4BP2 grouped by Cellular response to progesterone stimulus-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	N4BP2 →	+1.330	+1.460	.003	.002	3	5
LARGE_INTESTINE	SRSF9 →	+0.526	+1.326	.005	.005	3	5
LARGE_INTESTINE	RNF166 →	+0.991	+1.499	.009	.009	3	5
CNS	CBX2 →	+1.092	+1.050	<.001	<.001	3	4
CNS	TMEM178B →	-1.203	-0.995	.001	.007	3	4
LUNG_NSCLC_LUSC	LIPA →	-1.301	-1.322	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N4BP2 by Cellular response to progesterone stimulus activity — SOFT_TISSUE

Explore this box plot interactively →