Cellular response to glucocorticoid stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to glucocorticoid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4, GOT2, and ABCA8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucocorticoid stimulus activity versus TAF4 in LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TAF4 →	-0.430	-0.137	.001	<.001	3	5
LSCC	GOT2 →	-0.571	-0.162	.001	<.001	3	4
CCRCC	ABCA8 →	+0.516	+0.080	.001	.004	3	4
GBM	LINC02739 →	+0.326	+0.099	.004	.003	3	4
LSCC	MEDAG →	+1.052	+0.148	<.001	.002	3	4
GBM	LSM14B →	-0.526	-0.184	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071385 vs TAF4 — LUAD

Explore this scatter interactively →