Cellular response to steroid hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to steroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHS, NDUFA8, and LGALS3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to steroid hormone stimulus activity versus GAPDHS in COAD (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDHS →	+0.085	+0.206	<.001	.003	3	1
COAD	NDUFA8 →	+0.446	+0.170	.006	.004	3	1
COAD	LGALS3 →	+0.999	+0.157	.001	.007	3	1
COAD	INHBE →	+0.330	+0.162	.004	.001	3	1
COAD	RAG2 →	+0.035	+0.205	<.001	.003	3	1
COAD	APOF →	+0.145	+0.216	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071383 vs GAPDHS — COAD

Explore this scatter interactively →