Cellular response to steroid hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to steroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRG1, KLF3, and STBD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to steroid hormone stimulus activity versus LRG1 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRG1 →	+1.977	+0.133	.005	.003	3	7
BLOOD_Leukemia	KLF3 →	+1.700	+0.146	.001	.001	3	6
BLOOD_Leukemia	STBD1 →	+1.543	+0.197	<.001	<.001	3	5
LARGE_INTESTINE	P2RX4 →	+0.796	+0.184	.003	.001	3	5
LUNG_SCLC	LRP10 →	+1.864	+0.212	.004	.006	3	5
BLOOD_Leukemia	EHMT2 →	-0.727	-0.172	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071383 vs LRG1 — BLOOD_Lymphoma

Explore this scatter interactively →