Cellular response to growth hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to growth hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, WAS, and CORO1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to growth hormone stimulus activity versus STK10 in HNSC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STK10 →	+0.444	+0.090	<.001	<.001	3	9
HNSC	WAS →	+0.610	+0.067	<.001	<.001	3	9
LSCC	CORO1A →	+0.591	+0.090	<.001	<.001	3	9
LSCC	DOCK10 →	+0.504	+0.086	<.001	<.001	3	9
HNSC	DOCK2 →	+0.649	+0.078	<.001	<.001	3	9
GBM	AIF1 →	+0.805	+0.068	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071378 vs STK10 — HNSC

Explore this scatter interactively →