Cellular response to growth hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to growth hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EZH2_S380, CAVIN1_S127, and TCEAL1_S28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to growth hormone stimulus activity versus EZH2_S380 in LUAD (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EZH2_S380 →	-1.473	-0.231	<.001	<.001	3	5
OV	CAVIN1_S127 →	+0.956	+0.531	<.001	<.001	3	5
COAD	TCEAL1_S28 →	-0.590	-0.410	.001	.007	3	4
UCEC	ZNF687 →	-0.250	-0.141	<.001	<.001	3	4
LUAD	CAVIN1_S118 →	+0.715	+0.223	<.001	<.001	3	4
UCEC	CAVIN1_Y308 →	+0.799	+0.193	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071378 vs EZH2_S380 — LUAD

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