Cellular response to growth hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to growth hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAP2, SLC2A3, and TMEM14C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECAP2 grouped by Cellular response to growth hormone stimulus-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NECAP2 →	+0.563	+0.791	.001	.007	3	5
STOMACH	SLC2A3 →	+2.745	+0.899	.006	.008	3	5
BREAST	TMEM14C →	+0.580	+1.073	<.001	<.001	3	5
SOFT_TISSUE	MICALL1 →	+1.266	+1.048	<.001	.009	3	4
OESOPHAGUS	TMEM52B →	+2.525	+0.935	.003	.006	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM203 →	+1.110	+1.468	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECAP2 by Cellular response to growth hormone stimulus activity — BLOOD_Leukemia

Explore this box plot interactively →