Cellular response to growth hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to growth hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, FBXL15, and PCBP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to growth hormone stimulus activity versus GSR in LARGE_INTESTINE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSR →	-1.186	-0.676	<.001	.007	3	5
OVARY	FBXL15 →	-0.726	-0.995	.002	<.001	3	5
LIVER	PCBP2 →	-0.474	-1.783	.006	<.001	3	4
CNS	EEF1B2 →	-0.538	-0.706	.001	.003	3	4
CNS	PTPN1 →	+0.684	+0.750	<.001	.008	1	6
OESOPHAGUS	RBBP8 →	-1.336	-1.122	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071378 vs GSR — LARGE_INTESTINE

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