Cellular response to parathyroid hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to parathyroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D27P, CCDC69, and CD79B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to parathyroid hormone stimulus activity versus TBC1D27P in HNSC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TBC1D27P →	+0.347	+0.499	<.001	<.001	3	5
HNSC	CCDC69 →	+0.833	+0.602	<.001	<.001	3	5
HNSC	CD79B →	+0.821	+0.486	<.001	<.001	3	5
LSCC	MTERF1 →	-0.436	-0.492	.008	.002	3	5
LSCC	CHMP3 →	-0.455	-0.476	<.001	.003	3	5
COAD	BOLA3-AS1 →	-0.277	-0.657	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071374 vs TBC1D27P — HNSC

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