Cellular response to parathyroid hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to parathyroid hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM209, SPRED3, and PROS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM209 grouped by Cellular response to parathyroid hormone stimulus-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM209 →	+0.685	+1.124	<.001	.001	3	6
SKIN	SPRED3 →	-1.183	-1.076	.001	.001	3	4
LIVER	PROS1 →	+2.625	+1.550	.004	<.001	3	4
OVARY	KLHDC2 →	-0.658	-1.480	.006	<.001	3	4
BREAST	POLK →	-0.712	-0.873	.001	.001	3	4
CNS	SLC4A8 →	-1.134	-1.021	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM209 by Cellular response to parathyroid hormone stimulus activity — PANCREAS

Explore this box plot interactively →