Cellular response to parathyroid hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to parathyroid hormone stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RAP, DACH2, and CBY2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL1RAP grouped by Cellular response to parathyroid hormone stimulus-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL1RAP →	-0.138	-0.899	.007	.003	3	3
SKIN	DACH2 →	-0.219	-0.218	<.001	.001	3	3
SKIN	CBY2 →	-0.144	-0.266	.002	<.001	3	3
SKIN	XKR5 →	+0.155	+0.272	.009	.001	3	3
LIVER	OR2M5 →	-0.237	-1.963	.008	<.001	3	3
CNS	MYH9 →	-0.181	-0.509	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL1RAP by Cellular response to parathyroid hormone stimulus activity — BREAST

Explore this box plot interactively →