Cellular response to luteinizing hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to luteinizing hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP10, ITGA5, and RCN3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to luteinizing hormone stimulus activity versus FKBP10 in OV (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FKBP10 →	+0.528	+0.115	<.001	<.001	3	9
OV	ITGA5 →	+0.592	+0.136	<.001	<.001	3	9
COAD	RCN3 →	+0.773	+0.097	<.001	<.001	3	8
GBM	SERPINH1 →	+0.501	+0.121	<.001	<.001	3	8
BRCA	SERPING1 →	+0.628	+0.113	<.001	<.001	3	8
BRCA	TUBB6 →	+0.517	+0.099	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071373 vs FKBP10 — OV

Explore this scatter interactively →