Cellular response to gonadotropin stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to gonadotropin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMG8_S668, BAIAP2L1_T257, and WASF2_S284, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to gonadotropin stimulus activity versus SMG8_S668 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMG8_S668 →	+0.836	+0.802	<.001	<.001	3	3
OV	BAIAP2L1_T257 →	+1.532	+1.089	<.001	<.001	3	3
CCRCC	WASF2_S284 →	-0.547	-0.517	<.001	<.001	3	3
BRCA	PPARD_S50 →	+0.625	+0.778	<.001	<.001	3	3
UCEC	GOLGA4 →	-0.218	-0.508	<.001	.002	3	3
PDAC	SLC25A13 →	-0.358	-0.709	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071371 vs SMG8_S668 — OV

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