Cellular response to gonadotropin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to gonadotropin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLM, BCL7B, and GNG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to gonadotropin stimulus activity versus GCLM in LUNG_NSCLC_LUAD (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GCLM →	+1.238	+0.253	<.001	<.001	3	6
URINARY_TRACT	BCL7B →	+0.609	+0.315	.003	.004	3	5
URINARY_TRACT	GNG5 →	+0.526	+0.396	.007	.003	3	4
URINARY_TRACT	ZNF257 →	+1.328	+0.281	.003	.009	3	4
LUNG_NSCLC_LUAD	GSR →	+1.056	+0.206	.001	.003	3	4
CNS	PSMA5 →	+0.552	+0.292	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071371 vs GCLM — LUNG_NSCLC_LUAD

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