Cellular response to ethanol

Across TCGA patient cohorts, RNA activity of the Cellular response to ethanol pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKCE_S368, ARRB1_S412, and SAMHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ethanol activity versus PRKCE_S368 in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRKCE_S368 →	+0.542	+0.076	<.001	<.001	3	7
GBM	ARRB1_S412 →	+0.630	+0.072	<.001	<.001	3	6
UCEC	SAMHD1 →	+0.604	+0.092	<.001	<.001	3	6
OV	BIN1 →	+0.313	+0.033	.007	.006	3	6
LSCC	ANKRD44 →	+0.343	+0.065	<.001	<.001	3	6
UCEC	GSTM2 →	+0.601	+0.067	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071361 vs PRKCE_S368 — LSCC

Explore this scatter interactively →