Cellular response to ethanol

Across TCGA cell cohorts, RNA activity of the Cellular response to ethanol pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD2, H2BC15, and ZNF446, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ethanol activity versus SOD2 in LUNG_NSCLC_LUAD (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SOD2 →	+0.900	+0.427	.008	.006	3	5
CNS	H2BC15 →	+1.004	+0.388	<.001	<.001	3	4
BLOOD_Lymphoma	ZNF446 →	+0.826	+0.963	<.001	.002	3	3
PANCREAS	FAM177A1 →	+1.207	+0.261	.007	.006	3	3
BONE	RFPL3 →	-0.077	-1.269	.001	.003	2	4
CNS	VPS53 →	+0.678	+0.365	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071361 vs SOD2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →