Cellular response to dsRNA

Across TCGA patient cohorts, RNA activity of the Cellular response to dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18B, FOXM1, and CDC20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to dsRNA activity versus KIF18B in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF18B →	+1.251	+0.264	<.001	<.001	3	7
BRCA	FOXM1 →	+1.404	+0.319	<.001	<.001	3	6
BRCA	CDC20 →	+1.487	+0.267	<.001	<.001	3	6
OV	STIL →	+0.579	+0.115	.003	.002	3	6
BRCA	CCNB1 →	+0.975	+0.281	<.001	<.001	3	6
BRCA	TROAP →	+1.118	+0.312	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071359 vs KIF18B — BRCA

Explore this scatter interactively →