Cellular response to dsRNA

Across TCGA cell cohorts, RNA activity of the Cellular response to dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLGN2, SHLD1, and SYNPO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLGN2 grouped by Cellular response to dsRNA-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NLGN2 →	+0.924	+1.004	.004	.003	3	3
SOFT_TISSUE	SHLD1 →	-0.830	-1.198	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	SYNPO →	+1.876	+0.336	.002	.002	3	3
BONE	CEP43 →	+0.616	+0.223	.003	.002	3	3
LUNG_NSCLC_LUSC	ZBTB17 →	+0.725	+0.296	.001	.002	3	3
LUNG_NSCLC_LUSC	GLYR1 →	+0.724	+0.306	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLGN2 by Cellular response to dsRNA activity — SOFT_TISSUE

Explore this box plot interactively →