Cellular response to dsRNA

Across TCGA cell cohorts, RNA activity of the Cellular response to dsRNA pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNOT4, U2SURP, and NSMCE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNOT4 grouped by Cellular response to dsRNA-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CNOT4 →	+0.176	+0.165	.006	.001	2	4
PANCREAS	U2SURP →	-0.252	-0.193	.001	<.001	3	3
PANCREAS	NSMCE1 →	-0.445	-0.149	.008	<.001	3	3
LARGE_INTESTINE	MRGPRE →	+0.168	+0.284	.005	.006	3	3
LARGE_INTESTINE	CLK2P1 →	+0.281	+0.220	<.001	<.001	3	3
SKIN	PAGE4 →	+0.198	+0.116	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNOT4 by Cellular response to dsRNA activity — CNS

Explore this box plot interactively →