Cellular response to interleukin-1

Across TCGA patient cohorts, RNA activity of the Cellular response to interleukin-1 pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP12, PTGIS, and ECSCR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interleukin-1 activity versus AKAP12 in LUAD (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKAP12 →	+1.211	+0.247	<.001	<.001	3	8
LSCC	PTGIS →	+1.210	+0.228	<.001	<.001	3	7
OV	ECSCR →	+0.608	+0.385	<.001	.002	3	7
BRCA	CNRIP1 →	+0.837	+0.397	<.001	<.001	3	6
UCEC	ZNF385D →	+0.769	+0.186	.001	<.001	3	6
UCEC	CD1D →	+0.503	+0.113	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071347 vs AKAP12 — LUAD

Explore this scatter interactively →