Cellular response to type II interferon

Across TCGA patient cohorts, RNA activity of the Cellular response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, GZMH, and SIRPB1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to type II interferon activity versus IL2RB in CHOL (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	IL2RB →	+2.653	+0.079	<.001	<.001	3	34
SKCM	GZMH →	+2.656	+0.063	<.001	<.001	3	34
LAML	SIRPB1 →	+1.497	+0.057	<.001	<.001	3	34
DLBC	TLR8 →	+2.848	+0.104	<.001	.001	3	34
LAML	MEFV →	+2.100	+0.065	<.001	<.001	3	34
SKCM	LILRB1 →	+1.963	+0.065	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071346 vs IL2RB — CHOL

Explore this scatter interactively →