Cellular response to type II interferon

Across TCGA patient cohorts, RNA activity of the Cellular response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, FCGR2A, and PDPN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to type II interferon activity versus LILRB2 in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LILRB2 →	+0.693	+0.171	<.001	.004	3	8
OV	FCGR2A →	+0.812	+0.211	.002	.001	3	8
OV	PDPN →	+0.941	+0.239	<.001	<.001	3	8
UCEC	ZEB2 →	+0.928	+0.221	<.001	<.001	3	8
LSCC	SLC2A3 →	+1.059	+0.204	<.001	<.001	3	8
UCEC	ADGRE2 →	+0.783	+0.192	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071346 vs LILRB2 — COAD

Explore this scatter interactively →