Cellular response to type II interferon

Across TCGA cell cohorts, RNA activity of the Cellular response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN1, CDKN1A, and ASCC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SESN1 grouped by Cellular response to type II interferon-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SESN1 →	-1.084	-1.173	<.001	<.001	3	5
SKIN	CDKN1A →	-2.674	-1.238	<.001	<.001	3	4
LARGE_INTESTINE	ASCC3 →	-0.519	-0.276	.001	.001	3	4
SKIN	ZMAT3 →	-0.997	-1.003	<.001	<.001	3	4
SKIN	PTCHD4 →	-1.838	-1.164	<.001	<.001	3	4
SKIN	ACTA2 →	-1.844	-1.226	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SESN1 by Cellular response to type II interferon activity — SKIN

Explore this box plot interactively →