Cellular response to type II interferon

Across TCGA cell cohorts, RNA activity of the Cellular response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAGB, KCTD13, and PTHLH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to type II interferon activity versus RRAGB in LUNG_SCLC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRAGB →	+0.698	+0.192	<.001	.001	3	4
SOFT_TISSUE	KCTD13 →	+0.803	+0.244	.002	.009	2	5
OESOPHAGUS	PTHLH →	-3.492	-0.207	<.001	<.001	3	4
KIDNEY	FOSB →	+2.937	+0.256	.005	.004	3	4
STOMACH	FBXO11 →	+0.799	+0.217	.004	.001	3	4
STOMACH	CERS6 →	+1.091	+0.228	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071346 vs RRAGB — LUNG_SCLC

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