Cellular response to cGMP

Across TCGA patient cohorts, RNA activity of the Cellular response to cGMP pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, PABPC5, and PDE1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cGMP activity versus MEF2C in CCRCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MEF2C →	+0.621	+0.617	<.001	<.001	3	6
BRCA	PABPC5 →	+0.611	+0.435	.001	.007	3	6
UCEC	PDE1A →	+0.764	+0.249	.001	.001	3	5
UCEC	LMOD1 →	+1.210	+0.258	<.001	<.001	3	5
CCRCC	JAM3 →	+0.898	+0.590	<.001	<.001	3	5
UCEC	FANCA →	-0.585	-0.228	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071321 vs MEF2C — CCRCC

Explore this scatter interactively →