Cellular response to cGMP

Across TCGA cell cohorts, RNA activity of the Cellular response to cGMP pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB6, DOHH, and VSNL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cGMP activity versus SERPINB6 in LARGE_INTESTINE (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SERPINB6 →	-1.536	-0.711	.009	.001	3	3
STOMACH	DOHH →	-1.013	-0.408	<.001	.004	3	3
LIVER	VSNL1 →	-4.510	-1.893	.003	<.001	3	3
BLOOD_Lymphoma	DUSP19 →	-0.705	-1.259	.009	.008	3	2
BLOOD_Lymphoma	VSIG10 →	-1.516	-1.190	.001	.009	3	2
BLOOD_Lymphoma	LSMEM2 →	+0.248	+1.249	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071321 vs SERPINB6 — LARGE_INTESTINE

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