Cellular response to cAMP

Across TCGA cell cohorts, RNA activity of the Cellular response to cAMP pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2L6, RIC1, and POLR2H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2L6 grouped by Cellular response to cAMP-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UBE2L6 →	+1.616	+0.728	<.001	<.001	3	3
BLOOD_Leukemia	RIC1 →	+1.462	+0.967	.002	.002	3	3
KIDNEY	POLR2H →	-0.714	-1.346	.004	<.001	3	3
URINARY_TRACT	TMEM80 →	+1.205	+1.615	.003	<.001	3	3
BLOOD_Leukemia	KANK2 →	+1.583	+0.960	.001	.006	3	3
LIVER	PITPNM3 →	+2.121	+1.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2L6 by Cellular response to cAMP activity — BREAST

Explore this box plot interactively →