Cellular response to ATP

Across TCGA cell cohorts, RNA activity of the Cellular response to ATP pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3L, RPL3, and RPL22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3L grouped by Cellular response to ATP-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EIF3L →	-0.795	-0.468	<.001	.001	2	4
UPPER_AERODIGESTIVE_TRACT	RPL3 →	-0.711	-0.506	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	RPL22 →	-0.901	-0.426	.001	.001	2	4
UPPER_AERODIGESTIVE_TRACT	RPS24 →	-0.689	-0.422	.009	.005	3	3
UPPER_AERODIGESTIVE_TRACT	RPL10 →	-1.102	-0.499	.005	.002	3	3
UPPER_AERODIGESTIVE_TRACT	TOMM7 →	-0.790	-0.452	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3L by Cellular response to ATP activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →