Cellular response to ATP

Across TCGA cell cohorts, RNA activity of the Cellular response to ATP pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVP, NUDT8, and TMED5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ATP activity versus MVP in LUNG_NSCLC_LUSC (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MVP →	-2.733	-0.216	<.001	.008	3	6
BLOOD_Lymphoma	NUDT8 →	-1.057	-0.140	.003	.005	3	6
BLOOD_Myeloma	TMED5 →	-1.184	-0.201	.002	.009	3	5
LUNG_NSCLC_LUSC	KIFC3 →	-3.312	-0.231	.001	.003	3	5
BLOOD_Leukemia	NACC2 →	-1.566	-0.116	<.001	.002	3	5
LUNG_NSCLC_LUSC	TGOLN2 →	-1.481	-0.216	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071318 vs MVP — LUNG_NSCLC_LUSC

Explore this scatter interactively →