Cellular response to nicotine

Across TCGA patient cohorts, RNA activity of the Cellular response to nicotine pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK11, PPP1R13L_S158, and CLIC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nicotine activity versus DOCK11 in CCRCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DOCK11 →	-0.328	-0.055	<.001	.002	3	5
CCRCC	PPP1R13L_S158 →	-0.810	-0.075	.006	<.001	3	5
GBM	CLIC3 →	-1.127	-0.099	.006	.002	3	4
OV	NFKB2 →	+0.411	+0.073	<.001	.001	3	4
GBM	OTUB1 →	+0.248	+0.081	<.001	.001	2	5
LUAD	TTC9C →	+0.225	+0.062	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071316 vs DOCK11 — CCRCC

Explore this scatter interactively →