Cellular response to nicotine

Across TCGA patient cohorts, RNA activity of the Cellular response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF15, EXO1, and ARHGEF7-IT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nicotine activity versus KIF15 in CCRCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIF15 →	-0.493	-0.459	.004	.001	3	3
CCRCC	EXO1 →	-0.586	-0.348	.003	.002	2	4
GBM	ARHGEF7-IT1 →	-0.560	-0.110	.006	.007	3	3
BRCA	HECTD4 →	+0.539	+0.197	.009	.005	3	3
BRCA	TP53I11 →	+0.727	+0.148	<.001	.001	3	3
BRCA	MIR29B2CHG →	+0.585	+0.134	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071316 vs KIF15 — CCRCC

Explore this scatter interactively →