Cellular response to nicotine

Across TCGA cell cohorts, RNA activity of the Cellular response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB10, ING5, and CTBS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB10 grouped by Cellular response to nicotine-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZBTB10 →	+1.725	+1.197	.007	.006	3	5
OESOPHAGUS	ING5 →	+0.573	+1.256	.001	.001	3	4
LUNG_SCLC	CTBS →	-1.081	-0.219	.001	.003	3	4
LARGE_INTESTINE	NAF1 →	-0.663	-1.433	.004	<.001	3	4
STOMACH	DFFB →	-0.831	-1.444	.005	.006	3	4
BONE	FAM131C →	+1.510	+1.421	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB10 by Cellular response to nicotine activity — STOMACH

Explore this box plot interactively →