Cellular response to cocaine

Across TCGA patient cohorts, RNA activity of the Cellular response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL3, MARVELD3, and NPM1P29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cocaine activity versus METTL3 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	METTL3 →	+0.358	+0.251	<.001	<.001	3	4
OV	MARVELD3 →	+0.542	+0.619	.003	<.001	3	3
OV	NPM1P29 →	-0.573	-0.617	.001	.006	3	3
GBM	ZFYVE21 →	+0.450	+0.280	<.001	<.001	3	3
GBM	CRYM →	+1.306	+0.307	<.001	<.001	3	3
GBM	CD276 →	-0.720	-0.337	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071314 vs METTL3 — GBM

Explore this scatter interactively →