Cellular response to cocaine

Across TCGA cell cohorts, RNA activity of the Cellular response to cocaine pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A1, ZNF134, and CCDC28A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC39A1 grouped by Cellular response to cocaine-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC39A1 →	-0.160	-0.194	.009	.001	3	3
SKIN	ZNF134 →	-0.290	-1.546	.003	<.001	3	2
SKIN	CCDC28A →	+0.383	+1.546	.001	<.001	3	2
SKIN	JMJD6 →	-0.133	-1.600	<.001	<.001	3	2
BREAST	TTK →	-0.635	-1.294	.008	.006	3	2
BREAST	GARRE1 →	-0.310	-1.650	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC39A1 by Cellular response to cocaine activity — PANCREAS

Explore this box plot interactively →