Cellular response to cocaine

Across TCGA cell cohorts, RNA activity of the Cellular response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, PDZD8, and TP53BP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cocaine activity versus ABCA1 in CNS (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ABCA1 →	+2.020	+2.006	.002	<.001	3	3
CNS	PDZD8 →	+0.941	+2.006	.001	<.001	3	3
SKIN	TP53BP2 →	+0.705	+1.657	<.001	<.001	3	2
SKIN	ITPRIP →	+2.399	+1.657	.003	<.001	3	2
BREAST	TRABD →	-1.036	-1.762	.006	<.001	3	2
SKIN	AASS →	+0.715	+1.657	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071314 vs ABCA1 — CNS

Explore this scatter interactively →