Cellular response to retinoic acid

Across TCGA cell cohorts, RNA activity of the Cellular response to retinoic acid pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA1, HYAL2, and UTP18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to retinoic acid activity versus PHLDA1 in STOMACH (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PHLDA1 →	-2.778	-0.315	.004	.005	3	4
LUNG_NSCLC_LUAD	HYAL2 →	+0.709	+0.185	.005	.003	3	4
BLOOD_Myeloma	UTP18 →	-0.667	-0.208	.005	.001	3	4
LUNG_NSCLC_LUAD	ZNF429 →	+1.140	+0.181	.003	.001	3	4
SOFT_TISSUE	GPR137C →	+1.617	+0.425	.003	.003	3	4
SOFT_TISSUE	MED12 →	+0.885	+0.340	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071300 vs PHLDA1 — STOMACH

Explore this scatter interactively →