Cellular response to zinc ion

Across TCGA patient cohorts, RNA activity of the Cellular response to zinc ion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM12, MT1F, and MT1X, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to zinc ion activity versus RBM12 in COAD (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBM12 →	-0.154	-0.057	.005	<.001	3	8
OV	MT1F →	+1.383	+0.084	<.001	<.001	3	8
UCEC	MT1X →	+0.814	+0.106	<.001	<.001	3	7
GBM	HNRNPLL →	-0.247	-0.071	<.001	<.001	3	6
GBM	WDR5 →	-0.228	-0.049	.003	.004	3	6
GBM	XRCC1 →	-0.214	-0.041	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071294 vs RBM12 — COAD

Explore this scatter interactively →