Cellular response to zinc ion

Across TCGA cell cohorts, RNA activity of the Cellular response to zinc ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VHL, ZADH2, and RPS15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VHL grouped by Cellular response to zinc ion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VHL →	-0.835	-1.260	.004	.001	3	3
OVARY	ZADH2 →	-0.967	-0.823	<.001	.002	3	3
BLOOD_Myeloma	RPS15 →	+0.556	+1.054	.007	.007	3	3
BLOOD_Myeloma	ZNF780B →	-0.718	-1.404	.005	<.001	3	3
BLOOD_Myeloma	WSB2 →	-1.214	-1.498	.009	<.001	3	3
SKIN	SLC37A3 →	+1.076	+0.959	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VHL by Cellular response to zinc ion activity — BLOOD_Leukemia

Explore this box plot interactively →