Cellular response to zinc ion

Across TCGA cell cohorts, RNA activity of the Cellular response to zinc ion pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are BAY-61-3606, AICA Ribonucleotide, and Staurosporine, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAY-61-3606 grouped by Cellular response to zinc ion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BAY-61-3606 →	-0.648	-0.170	.001	.008	3	3
BLOOD_Leukemia	AICA Ribonucleotide →	-0.511	-0.231	.005	.003	3	2
BLOOD_Leukemia	Staurosporine →	-0.624	-0.196	.023	.034	3	2
BLOOD_Leukemia	SB590885 →	-0.352	-0.160	.010	.008	3	2
BLOOD_Leukemia	CP466722 →	-0.460	-0.173	.006	.002	3	2
BLOOD_Leukemia	Midostaurin →	-0.854	-0.249	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-61-3606 by Cellular response to zinc ion activity — BLOOD_Leukemia

Explore this box plot interactively →