Cellular response to manganese ion

Across TCGA patient cohorts, RNA activity of the Cellular response to manganese ion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HB, ASAP3, and BAG6_T1053, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to manganese ion activity versus P4HB in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	P4HB →	+0.238	+0.057	.002	.001	3	5
LUAD	ASAP3 →	+0.244	+0.045	<.001	<.001	3	4
BRCA	BAG6_T1053 →	+0.462	+0.034	.009	.004	3	4
LUAD	TMEM263 →	+0.188	+0.035	.006	.005	3	4
OV	SRSF2_S191 →	-1.112	-0.057	.001	.002	3	4
OV	ELN →	+0.697	+0.049	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071287 vs P4HB — PDAC

Explore this scatter interactively →