Cellular response to manganese ion

Across TCGA patient cohorts, RNA activity of the Cellular response to manganese ion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRK2_S955, MYCBP2_S2319, and VGLL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to manganese ion activity versus LRRK2_S955 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRK2_S955 →	+1.457	+0.799	<.001	<.001	3	5
UCEC	MYCBP2_S2319 →	+0.521	+0.291	.001	<.001	3	4
HNSC	VGLL4 →	-0.340	-0.469	<.001	.001	3	4
UCEC	EVI2B_S263 →	+0.998	+0.364	<.001	<.001	3	4
LSCC	LRRK2_S973 →	+0.980	+0.873	<.001	<.001	3	4
PDAC	EIF2AK3 →	+0.335	+0.632	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071287 vs LRRK2_S955 — LSCC

Explore this scatter interactively →