Cellular response to manganese ion

Across TCGA cell cohorts, RNA activity of the Cellular response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YBEY, TFPT, and TEX14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YBEY grouped by Cellular response to manganese ion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	YBEY →	+1.143	+0.277	<.001	<.001	3	5
LUNG_NSCLC_LUSC	TFPT →	+0.884	+0.377	.009	.003	3	4
BLOOD_Myeloma	TEX14 →	+3.268	+0.295	.005	<.001	2	4
SOFT_TISSUE	FKBP14 →	-1.019	-0.247	<.001	.008	3	3
SOFT_TISSUE	RAB23 →	-1.155	-0.227	.002	.002	3	3
SOFT_TISSUE	GPX8 →	-0.846	-0.245	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YBEY by Cellular response to manganese ion activity — BREAST

Explore this box plot interactively →