Cellular response to manganese ion

Across TCGA cell cohorts, RNA activity of the Cellular response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2S1, TRMT61A, and CCDC85C, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to manganese ion activity versus EIF2S1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EIF2S1 →	+1.126	+0.082	<.001	<.001	3	12
OVARY	TRMT61A →	+0.778	+0.079	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	CCDC85C →	+1.004	+0.061	.001	.006	3	11
UPPER_AERODIGESTIVE_TRACT	EIF2B2 →	+1.093	+0.080	.005	.003	3	11
OESOPHAGUS	TEDC1 →	+1.592	+0.114	<.001	<.001	3	11
PANCREAS	ACTN1 →	+1.541	+0.103	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071287 vs EIF2S1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →