Cellular response to magnesium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to magnesium ion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HOOK1, ANK3, and CRTAP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to magnesium ion activity versus HOOK1 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HOOK1 →	+0.743	+0.104	<.001	<.001	3	8
UCEC	ANK3 →	+0.523	+0.156	<.001	<.001	3	8
BRCA	CRTAP →	-0.456	-0.052	.002	.002	3	7
GBM	DLG3 →	+0.582	+0.106	<.001	<.001	3	7
CCRCC	ETFDH →	+0.350	+0.117	.002	.001	3	7
COAD	PLS1 →	+0.518	+0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071286 vs HOOK1 — GBM

Explore this scatter interactively →